| Movie | Grey's Anatomy |
| Director(s) | Shonda Rhimes |
| Producer(s) | Allan Heinberg, Andy Reaser, Betsy Beers, Debbie Allen, James D. Parriott, Jeannine Renshaw |
| Writer(s) | Elisabeth Finch |
| Running Time | 41m |
| Release Date | March 27, 2005 |
Ellen Kathleen Pompeo playing as Dr. Meredith Grey
 | |
| Role | Dr. Meredith Grey |
| Real Name | Ellen Kathleen Pompeo |
| Age | 52 years old (in 2022) |
| Profession | Actress, Director and Producer |
| Nationality | American |
| Known for | Meredith Grey on Grey's Anatomy |
Chandra Danette Wilson playing as Dr. Miranda Bailey
 | |
| Role | Dr. Miranda Bailey |
| Real Name | Chandra Danette Wilson |
| Age | 52 years old (in 2022) |
| Profession | Actress, Director |
| Nationality | American |
| Known for | His Intense Method Acting Style, Often Transforming His Body Drastically For His Roles |
Justin Willman Chambers playing as Dr. Alex Karev
 | |
| Role | Dr. Alex Karev |
| Real Name | Justin Willman Chambers |
| Age | 51 years old (in 2022) |
| Profession | Actor and Former Model |
| Nationality | American, German |
| Known for | Having worked for a number of brands such as Armani, Calvin Klein, and Dolce & Gabbana across Europe, Japan, and the United States |
Kevin McKidd playing as Dr. Owen Hunt
 | |
| Role | Dr. Owen Hunt |
| Real Name | Kevin McKidd |
| Age | 48 years old (in 2022) |
| Profession | Actor, Director, Singer, TV Actor |
| Nationality | Scottish |
| Known for | Dan Vasser |
Jesse Wesley Williams playing as Dr. Jackson Avery, Jackson Avery
 | |
| Role | Dr. Jackson Avery, Jackson Avery |
| Real Name | Jesse Wesley Williams |
| Age | 40 years old (in 2022) |
| Profession | Actor, Director, Producer and Activist |
| Nationality | American |
| Known for | Beyond The Break, The Cabin In The Woods |
Patrick Galen Dempsey playing as Dr. Derek Shepherd
 | |
| Role | Dr. Derek Shepherd |
| Real Name | Patrick Galen Dempsey |
| Age | 56 years old (in 2022) |
| Profession | Actor and Race Car Driver |
| Nationality | American |
| Known for | Ronald Miller In Can't Buy Me Love (1987), Dr. Derek Shephard In Grey's Anatomy, Detective Mark Kincaid in Scream 3. |
Sara Elena Ramírez playing as Dr. Callie Torres
 | |
| Role | Dr. Callie Torres |
| Real Name | Sara Elena Ramírez |
| Age | 46 years old (in 2022) |
| Profession | Actress |
| Nationality | Mexican, American |
| Known for | Sara |
Camilla Luddington playing as Dr. Jo Wilson, Dr. Jo Karev, Jo Karev
 | |
| Role | Dr. Jo Wilson, Dr. Jo Karev, Jo Karev |
| Real Name | Camilla Luddington |
| Age | 38 years old (in 2022) |
| Profession | Actress |
| Nationality | American-British |
| Known for | Darth Maul "Star Wars I" |
Sandra Miju Oh playing as Dr. Cristina Yang
 | |
| Role | Dr. Cristina Yang |
| Real Name | Sandra Miju Oh |
| Age | 50 years old (in 2022) |
| Profession | Actress |
| Nationality | Canadian |
| Known for | Killing Eve |
Sarah White Drew playing as Dr. April Kepner
 | |
| Role | Dr. April Kepner |
| Real Name | Sarah White Drew |
| Age | 41 years old (in 2022) |
| Profession | Actress |
| Nationality | American |
| Known for | Hannah Rogers |
Kimberly Jayne Raver playing as Dr. Teddy Altman
 | |
| Role | Dr. Teddy Altman |
| Real Name | Kimberly Jayne Raver |
| Age | 52 years old (in 2022) |
| Profession | Actress, Producer |
| Nationality | American |
| Known for | The 'YouTube' channels 'RonnieSwanks' and 'IamRonnieBanks |
Eric Dane playing as Dr. Mark Sloan
 | |
| Role | Dr. Mark Sloan |
| Real Name | Eric Dane |
| Age | 49 years old (in 2022) |
| Profession | Actor |
| Nationality | American |
| Known for | Dr. Mark Sloan on Grey's Anatomy |
Katherine Marie Heigl playing as Dr. Izzie Stevens
 | |
| Role | Dr. Izzie Stevens |
| Real Name | Katherine Marie Heigl |
| Age | 43 years old (in 2022) |
| Profession | Actress and Former Fashion Model |
| Nationality | American |
| Known for | True Luv (2010), Like a Boss (2020) |
Chyler Leigh West playing as Dr. Lexie Grey
 | |
| Role | Dr. Lexie Grey |
| Real Name | Chyler Leigh West |
| Age | 39 years old (in 2022) |
| Profession | Actress, Model, Singer |
| Nationality | American |
| Known for | Footballer |
Chris Carmack playing as Dr. Atticus Lincoln
 | |
| Role | Dr. Atticus Lincoln |
| Real Name | Chris Carmack |
| Age | 38 Years 10 Month(s) |
| Profession | Actor |
| Nationality | American |
Deborah Kaye Allen playing as Dr. Catherine Avery
 | |
| Role | Dr. Catherine Avery |
| Real Name | Deborah Kaye Allen |
| Age | 72 years old (in 2022) |
| Profession | Actress |
| Nationality | American |
| Known for | Hudson Street |